Same problem with Chrome, IE, Firefox & Opera, under several Win7, Win10 operating systems (home computers, laptops, enterprise laptops, virtual machines with Win...). Tried all configs possible without luck. Tried all releases since 8.2...
Not heavy load or copying/cutting large amount of data. Only pressing some shorcuts in remote desktop and opening some windows like control panel. Sometimes we get the guacamole error every minute or less, sometimes every few minutes... but always we get the message.
One guy tested with an Ipad and it worked without errors...
On the other hand, legacy RDP works well.