We have Poor Video/Audio skype for business on-prem via vpn (ESP) mode once we have 10-20 video sessions . PSA-3000 ..based on cpu/memory/trafic usage on dashbord everything looks great..
I have heard about to send skype trafic outside the vpn tunnel but is that posilbe? or do´s it exist any oterh bestpractise how to handle skype video/audio trafic via vpn pulse secure to do have delay on trafic ?
Skype for Business (S4B) optimization using Split tunnellng - https://gallery.technet.microsoft.com/lync/Enhance-your-Skype-for-744f17cb/file/178379/1/Enhance%20S...
Office 365 URLs and IP address ranges which you need deny on the Split tunnleing policy - https://docs.microsoft.com/en-us/office365/enterprise/urls-and-ip-address-ranges
Had some past experiences with poor screen share, changing the screen share protocol to RDP or some other lightweight equivalent (if I recall correctly) had positive effect on the sessions.
I always prefer for traffic of any cloud-based or internet facing applications to be sent outside the tunnel unless there is a very strong business reason to send it via the tunnel. Especially any bandwidth heavy or real time applications like audio/video.
So if your skype on-prem servers are accessible via internet then send them outside the tunnel, especially right now when everyone is working remote.