I am running a MAG2610 on 8.1R4. So far, Windows10 works fine with the Pulse Secure client that come with this version (5.1.4 build 60057). Also the webpages work fine except Window Edge does not support ActiveX (Terminal Services control) for Remote Desktop. But Windows 10 also comes with IE11 which does support the ActiveX. So far, looks like there are no problems.
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