Yes, it is possible by using FQDN based split tunneling policy which has the FQDN of the backend site.   Reference: https://www-prev.pulsesecure.net/download/techpubs/current/1626/pulse-client/pulse-secure-client-desktop/9.1Rx/FQDN-based-split-tunneling-deployment-guide.pdf   Known issue: https://kb.pulsesecure.net/articles/Pulse_Secure_Article/KB44429/?kA13Z000000L3Fn ... View more